UNASYN 1500 MG 1 VIAL 5ML

for adult:

Gynecologic Infections

1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day

Intra-Abdominal Infections

1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day

Skin & Skin Structure Infections

1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV/IM q6hr; not to exceed 12 g/day

Orbital Cellulitis

3 g (2 g ampicillin + 1 g sulbactam) IV q6hr

Pelvic Inflammatory Disease

3 g (2 g ampicillin + 1 g sulbactam) IV q6hr

Pneumonia

Aspiration or community acquired: 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 5 or more days

Hospital acquired: 3 g IV q6hr for 5 or more days

Urinary Tract Infections

Pyelonephritis: 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 14 days

Acute Bacterial Rhinosinusitis (Off-label)

Severe infection requiring hospitalization

1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 5-7 days

Endocarditis (Off-label)

Enterococcus infection resistant to penicillin/susceptible to aminoglycosides: 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 6 weeks if not aminoglycoside resistant; >6 weeks if aminoglycoside resistant

HACEK infection: 3 g (2 g ampicillin + 1 g sulbactam) IV q6hr for 4 weeks

Dosing Modifications

Renal impairment

• CrCl 5-14 mL/min/1.73 m²: 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) IV q24hr
• CrCl 15-29 mL/min/1.73 m²: 3 g (2 g ampicillin + 1 g sulbactam) IV q12hr
• CrCl ≥ 30 mL/min/1.73 m²: No dose adjustment necessary

 for Pediatric:

Skin Infections

>1 year (<40 kg): 200 mg/kg/day IV divided q6hr; not to exceed 14 days of therapy  

>1 year (>40 kg): 1.5 g (1 g ampicillin + 0.5 g sulbactam) to 3 g (2 g ampicillin + 1 g sulbactam) q6hr; not to exceed 12 g/day

Epiglottitis

Children and adolescents: 100-200 mg ampicillin/kg/day IV divided q6hr  

Mild/Moderate Infection

>1 month-1 year: 100-150 mg ampicillin/kg/day IV/IM divided q6hr  

>1 year: 100-200 mg ampicillin/kg/day IV/IM divided q6hr

Meningitis/Severe Infections

>1 month-1 year: 200-300 mg ampicillin/kg/day IV/IM divided q6hr  

>1 year: 200-400 mg ampicillin/kg/day IV/IM divided q6hr

Peritonsillar and Retropharyngeal Abscess

Children and adolescents: 200 mg ampicillin/kg/day IV divided q6h