-Dyspepsia: Oral: 40 mg once daily for up to 8 weeks. -Esophagitis: Oral: 20 to 40 mg twice daily for an 8-week trial. Once 8-week trial is complete and remission is achieved, the dose may be gradually lowered. -Helicobacter pylori eradication: Oral: Clarithromycin triple regimen: 20 to 40 mg twice daily in combination with clarithromycin 500 mg twice daily and either amoxicillin 1 g twice daily or metronidazole 500 mg 3 times daily; continue regimen for 14 days. Eradication rates with clarithromycin-based regimens ≤85%. -Sequential regimen: 20 mg twice daily plus amoxicillin 1 g twice daily for 5 to 7 days; then continue esomeprazole along with clarithromycin 500 mg twice daily, and either metronidazole or tinidazole 500 mg twice daily for 5 to 7 days. -Peptic ulcer disease, treatment of complicated ulcers (perforation, penetration, or gastric outlet obstruction): Oral, IV: 40 mg twice daily for 4 weeks, followed by 40 mg once daily. Duration depends on the location and etiology of ulcer. -Treatment of bleeding peptic ulcers: IV: Continuous infusion: Loading dose of 80 mg, followed by 8 mg/hour continuous infusion for a total of 72 hours, IV: Intermittent dosing: Loading dose of 80 mg, followed by 40 mg every 12 hours -Prevention of NSAID-induced gastric ulcers: Oral: Esomeprazole: 20 to 40 mg once daily for up to 6 months. -Gastroesophageal reflux: Oral: Esomeprazole: 20 mg once daily for 4 weeks; may consider an additional 4 weeks of treatment if symptoms do not resolve. -Pediatric dosing: Erosive esophagitis associated with GERD: Oral: Infants: 3 to 5 kg: 2.5 mg once daily for up to 6 weeks, >5 to 7.5 kg: 5 mg once daily for up to 6 weeks,>7.5 kg: 10 mg once daily for up to 6 weeks. Children 1 to 11 years: <20 kg: 10 mg once daily for 8 weeks, ≥20 kg: 10 or 20 mg once daily for 8 weeks. Children ≥12 years and Adolescents: 20 to 40 mg once daily for 4 to 8 weeks.