Used for: Type 2 diabetes mellitus
Metformin lowers blood sugar levels by reducing the amount of glucose produced by the liver, increasing the body’s sensitivity to insulin, and slowing down the absorption of glucose from the intestines.Additional information:Glucophage XR is an extended-release tablet, which means that it releases the metformin slowly over time. This helps to reduce side effects such as stomach upset and nausea.Glucophage XR can be used alone or in combination with other diabetes medications, such as insulin.It is important to monitor your blood sugar levels closely while taking Glucophage XR.WarningsGlucophage XR can cause a rare but serious condition called lactic acidosis. Lactic acidosis is a buildup of lactic acid in the blood that can be fatal. Symptoms of lactic acidosis include:Unusual muscle painFatigueDrowsinessDifficulty breathingStomach upsetNauseaVomitingIf you experience any of these symptoms, stop taking Glucophage XR and seek medical attention immediately.Glucophage XR is also contraindicated in patients with the following conditions:Renal impairmentHepatic impairmentActive heart failureAcute myocardial infarctionSevere infectionAlcoholic ketoacidosisHistory of lactic acidosisGlucophage XR should be used with caution in patients who are at increased risk of lactic acidosis, such as the elderly, patients with impaired renal function, and patients taking other medications that can increase the risk of lactic acidosis.Drug interactionsGlucophage XR can interact with a number of other medications, including:InsulinSulfonylureasMeglitinidesThiazolidinedionesGlucagon-like peptide-1 (GLP-1) receptor agonistsSGLT2 inhibitorsCimetidineDigoxinProcaine amideQuinineVancomycinIt is important to tell your doctor about all of the medications you are taking before starting Glucophage XR.Pregnancy and breastfeedingGlucophage XR should not be used during pregnancy or breastfeeding unless otherwise directed by your doctor.StorageStore Glucophage XR at room temperature, away from moisture and heat.