Medical Description
Proton pump inhibitor used in the treatment of dyspepsia, gastroesophageal reflux disease, Helicobacter pylori eradication, primary prevention of nonsteroidal anti-inflammatory drugs-induced ulcers, treatment and prevention of peptic ulcer disease.
Indication & Usage
-Dyspepsia: Oral: 20 to 40 mg once daily for a 4- to 8-week; can be continued for a longer duration in patients with symptom improvement. -Gastroesophageal reflux disease: Initial therapy: Mild/intermittent disease (<2 episodes/week) and no evidence of erosive esophagitis: Oral: 20 mg once daily, can increase to 40 mg once daily after 4 to 8 weeks if necessary. Discontinue once asymptomatic for 8 weeks. Severe and/or frequent symptoms (≥2 episodes/week), and/or erosive esophagitis: Oral: 40 mg once daily; once symptoms are controlled, continue for at least 8 weeks. -Helicobacter pylori eradication: Oral: 40 mg or 80 mg twice daily as part of an appropriate combination regimen with antibiotics. -Nonsteroidal anti-inflammatory drugs (including aspirin)-induced ulcers, primary prevention: Oral: 20 to 40 mg once daily for the duration of high-risk NSAID use. -Treatment and secondary prevention of peptic ulcer disease: Uncomplicated ulcer: Oral: 40 mg once daily. Duration depends on the size, location, and cause of ulcer and ranges from 4 to 8 weeks, Complicated ulcer (perforation, penetration, or gastric outlet obstruction): Oral, IV: 40 mg twice daily for 4 weeks, followed by 40 mg once daily. Duration depends on the location and etiology of ulcer, Bleeding ulcer: IV: Continuous infusion: Loading dose of 80 mg, followed by 8 mg/hour continuous infusion for a total of 72 hours, IV: Intermittent dosing: Loading dose of 80 mg, followed by 40 mg every 12 hours. -Stress ulcer prophylaxis in critically ill patients: IV: 40 mg once daily : Oral or via nasogastric tube: 40 mg once daily. -Pediatric Gastroesophageal reflux disease (GERD): Infants, Children, and Adolescents: Oral: 1 to 2 mg/kg/day once daily; maximum daily dose: 40 mg/day.