Tareg 40 mg 15 Tablets

-Chronic hypertension: For patients who warrant combination therapy (BP >20/10 mm Hg above goal or suboptimal response to initial monotherapy), may use with another appropriate agent (eg, long-acting dihydropyridine calcium channel blocker or thiazide diuretic): Oral: Initial: 80 to 160 mg once daily; evaluate response after ~2 to 4 weeks and titrate dose (eg, increase the daily dose by doubling) as needed up to a maximum of 320 mg once daily; if additional blood pressure control is needed, consider combination therapy. -Acute coronary syndromes: Non–ST-elevation acute coronary syndrome: Oral: Initial: 20 mg twice daily; may increase dose as tolerated up to 160 mg twice daily under close monitoring to avoid hypotension. While in case of ST-elevation myocardial infarction: Oral: Initial: 20 mg twice daily; may increase dose as tolerated up to 160 mg twice daily under close monitoring to avoid hypotension. -Heart failure: Oral: Initial: 20 to 40 mg twice daily; increase dose (eg, double) every ≥2 weeks based on response and tolerability to a target dose of 160 mg twice daily. -Proteinuric chronic kidney disease: Oral: Initial: 40 to 80 mg twice daily depending on BP; can be titrated to 160 mg twice daily based on BP response and tolerability. -Pediatric dosing: -Hypertension: Children and Adolescents <17 years: Oral: Initial: 1 mg/kg/dose once daily; maximum initial daily dose: 40 mg/day; some patients may require a higher initial dose of 2 mg/kg/dose once daily. May titrate to effect up to a maximum daily dose: 4 mg/kg/day not to exceed 160 mg/day. Adolescents ≥17 years: Oral: Initial: 80 mg or 160 mg once daily; some patients may require a higher initial dose. May titrate to effect up to a maximum daily dose: 320 mg/day.